Title
Algorithms for the interpretation of HIV-1 genotypic drug resistance information
Author
Faculty/Department
Faculty of Applied Economics
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Antiviral research. - Amsterdam
Volume/pages
71(2006) :2-3 , p. 335-342
ISSN
0166-3542
ISI
000240381200033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Drug resistance testing has proven its use to guide treatment decisions in HIV-1 infected patients. Genotyping is the preferred technique for clinical drug resistance testing. Many factors complicate the interpretation of mutations towards therapy response, such that an interpretation system is necessary to help the clinical virologist. No consensus interpretation exists to date and experts often have quite different opinions. As a result, several algorithms for the interpretation of HIV-1 genotypic drug resistance information have been designed. Clinical evaluation of their genotypic interpretation is not always straightforward. We describe a few publicly available systems and their clinical evaluation. We also stress that in addition to drug resistance, for effective management of HIV infection the clinician needs to take into account all potential causes of treatment failure. Successful therapy heavily relies on the expertise of the clinician.
E-info
https://repository.uantwerpen.be/docman/iruaauth/fe21cd/8255245e403.pdf
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Handle