Title
Quantitative and qualitative evaluation of dermal elastin of draught horses with chronic progressive lymphoedema Quantitative and qualitative evaluation of dermal elastin of draught horses with chronic progressive lymphoedema
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
London ,
Subject
Veterinary medicine
Human medicine
Source (journal)
Journal of comparative pathology. - London
Volume/pages
140(2009) :2/3 , p. 132-139
ISSN
0021-9975
ISI
000263962100006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Chronic progressive lymphoedema (CPL) in horses, a disease of certain draught breeds, is associated with altered elastin metabolism. The characteristic lesions are seen in the skin of the lower (distal) limbs. This study was based on horses of susceptible breeds, with and without CPL, and on horses of a non-susceptible breed. Skin samples were obtained for examination from the neck (considered a non-affected region) and from the distal limb. The skin lesions were characterized histologically and the dermal elastic fibres were evaluated morphologically and quantitatively. In all horses the mean elastin concentrations were highest in the superficial dermis, gradually decreasing in the mid-dermis and deep dermis. As compared with horses of a non-susceptible breed, affected horses had increased amounts of dermal elastin in both the distal limb and neck, while non-affected horses of a susceptible breed had decreased amounts. The findings support an earlier hypothesis that CPL of horses is a generalized disease. Reduced efficiency of the elastic network in supporting the dermal lymphatics may explain the development of CPL. (C) 2008 Published by Elsevier Ltd.
E-info
https://repository.uantwerpen.be/docman/iruaauth/5e9ab5/4071398.pdf
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