Title
The blood-brain barrier in trauma, stroke and edema The blood-brain barrier in trauma, stroke and edema
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
conferenceObject
Publication
Amsterdam :Elsevier, [*]
Subject
Human medicine
Source (book)
11th Drug Transporters and Diseased Brain Conference, October 6-9, 2004, Girona, Spain
ISBN
0-444-51716-2
ISI
000230356700018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Successful research on human disease mechanisms and adequate pharmacotherapy depends on the availability of consistent and relevant animal models. For complex pathologies e.g. stroke and cerebral trauma it is highly important that the experimental models as much as possible mimic the pathogenesis and that drugs are delivered at the right time and the right place. Thereby it is not sufficient to counteract solely the endpoint of a traumatic or ischemic process i.e. irreversible neuronal cell death, but also to interfere with changes in other brain constituents e.g. the glial and endothelial compartments. Both are structural components of the blood-brain barrier and play a key role in the development of secondary phenomena as edema formation. The course and structural aspects of edema formation will be discussed, based on experience with several animal models of brain ischemia and trauma. It is concluded that stroke and trauma therapy is not only a matter of neurons and that acute treatment should focus on prevention of brain swelling. (c) 2005 Elsevier B.V. All rights reserved.
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