Title
Nuclear chromatin patterns in normal, hyperplastic and atypical endometrium Nuclear chromatin patterns in normal, hyperplastic and atypical endometrium
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
Saint Louis, Mo. ,
Subject
Biology
Human medicine
Source (journal)
Analytical and quantitative cytology and histology. - Saint Louis, Mo.
Volume/pages
23(2001) :2 , p. 144-150
ISSN
0884-6812
ISI
000168174600008
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
OBJECTIVE: To characterize the nuclei of endometrial lesions for the diagnostic categories of normal glandular tissue, simple hyperplasia, atypical hyperplasia and adenocarcinoma of the endometrium, with the specific goal of probing for heterogeneity. STUDY DESIGN: For each diagnostic category the images of 360 nuclei were recorded on a high-resolution video microphotometer. Features descriptive of the statistical and spatial distribution of nuclear chromatin were computed for each nucleus. A nonsupervised learning algorithm, P-index, was Employed to establish subsets of nuclei within each diagnostic category and to determine whether these subsets were statistically significantly different in the nuclear chromatin pattern. RESULTS: Lesions from cases of hyperplasia, atypical hyperplasia and adenocarcinoma of the endometrium each contained several subsets of nuclei with statistically significantly different chromatin patterns. For one such subset from each diagnostic category, a clear trend of progression toward adenocarcinoma could be demonstrated. CONCLUSION: The nuclei in endometrial lesions represent a highly heterogeneous set. Any measure of lesion progression or regression due to chemopreventive intervention, in an individual case, will have to examine the proportion of nuclei in each of these subsets as well as measures of deviation from normal for each subset.
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