Publication
Title
Cisplatin - DNA adducts and protein-bound platinum in blood of testicular cancer patients
Author
Abstract
DNA adducts formed by cisplatin [cis-diamminedichloroplatinum(II)] were measured in blood samples from 48 testicular cancer patients treated in four centers in Europe during four six cycles with cisplatin infusions on five successive days (total samples, 112). Total protein-bound platinum (Pt) in blood was also measured (total samples, 84). The mean on main DNA adduct, cis-Pt(NH3)(2) d(pGpG) (Pt-GG), was 0.75 fmol/mu g DNA [standard deviation (SD) = 0.66] on the first day of the first cycle, increased after the infusion at day 5 of the cycle (mean 1.74 fmol/mu g DNA, SD = 0.90) and decreased on the following day (mean 1.09 fmol/mu g DNA, SD = 0.62). In subsequent cycles, there was a tendency to an increase in the mean Pt-GG levels. The values of protein-bound Pt in blood showed little reduction between day 5 and 6 of each cycle, and a stable increase during the course of the therapy. Strong correlations were seen between day 1, 5 and 6 of the first cycle for both Pt-GG and protein-bound Pt in blood. A strong correlation (r = 0.62, p<0.001, 69 pairs) was found between the levels of Pt-GG and protein-bound Pt. Only two patients relapsed during the follow-up; therefore, the analysis of the association between Pt-GG levels and response to therapy was not informative. The results of this study suggest that DNA adducts formed by cisplatin at the beginning of chemotherapy are predictive of values found during later days and cycles, and that the value of protein-bound Pt in blood is predictive of the value of DNA adducts. [(C) 1998 Rapid Science Ltd.].
Language
English
Source (journal)
Anti-cancer drugs: an international journal on anti-cancer agents. - Philadelphia, Pa
Publication
Philadelphia, Pa : 1998
ISSN
0959-4973
Volume/pages
9:2(1998), p. 125-129
ISI
000071866300002
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 29.02.2012
Last edited 02.10.2017
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