Title
Blood coagulation and platelet aggregation in major depression
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Journal of affective disorders. - Amsterdam
Volume/pages
40(1996) :1-2 , p. 35-40
ISSN
0165-0327
ISI
A1996VG57100005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recently, it was found that the plasma of depressed patients significantly reduced the primary and secondary platelet aggregation to aggregating agents, such as ADP and collagen, in platelet rich plasma (PRP) of normal volunteers. Other authors found significantly decreased maximum amplitudes of adrenaline-induced platelet aggregation in major depressed patients versus normal controls. The aim of the present study was to examine platelet aggregation and blood coagulation in depression. Toward this end, the authors have measured secondary platelet aggregation to ADP and collagen, and the activated partial thromboplastin time (APTT) and prothrombin time (PT) in 16 normal volunteers, 16 minor, 40 simple major and 23 melancholic subjects. There were no significant differences in ADP- or collagen-induced platelet aggregability, APTT or PT between normal controls, minor, simple major or melancholic depressed patients. There were no significant relationships between severity of depression and APTT, PT or platelet aggregability to ADP or collagen. It is concluded that blood coagulation and platelet aggregability to ADP and collagen are probably not disordered in major depression.
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