Title
Pharmacokinetics and tolerance of intravenous and intramuscular phylloquinone (vitamin K-1) mixed micelles formulation Pharmacokinetics and tolerance of intravenous and intramuscular phylloquinone (vitamin K-1) mixed micelles formulation
Author
Publication type
article
Publication
London ,
Subject
Pharmacology. Therapy
Source (journal)
British journal of clinical pharmacology. - London
Volume/pages
41() :6 , p. 517-523
ISSN
0306-5251
ISI
A1996UP45400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
1 The pharmacokinetics and tolerance of phylloquinone (vitamin K-1) mixed micelles formulation (Konakion(R) MM) were evaluated, in normal human adult volunteers (n = 30) using an open randomized crossover design protocol following a 10 mg intravenous or intramuscular injection. 2 Blood samples were collected for up to 12 h after the intravenous and up to 72 h after the intramuscular injections and the phylloquinone (vitamin K-1) levels determined by reversed phase h.p.l.c. with fluorometric detection after post-column electrochemical reduction. 3 Konakion(R) MM was well tolerated after either route of administration. Pharmacokinetic analysis of plasma phylloquinone (vitamin K-1) concentration vs time profiles revealed that in one-fifth of the subjects systemic availability of intramuscular phylloquinone (vitamin K-1) was below 65%. 4 Our data suggest that due to sustained, but irregular and unpredictable absorption of the phylloquinone (vitamin K-1) from the depot site, the intramuscular route of Konakion(R) MM administration is not suitable and thus not recommended. 5 Konakion(R) MM i.v. is indicated to be well tolerated and effective in antagonizing coumarin-type-anticoagulants like Marcoumar(R)
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UP45400006&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UP45400006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UP45400006&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848