Title
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Pharmacokinetics and tolerance of intravenous and intramuscular phylloquinone (vitamin K-1) mixed micelles formulation
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Author
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Abstract
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1 The pharmacokinetics and tolerance of phylloquinone (vitamin K-1) mixed micelles formulation (Konakion(R) MM) were evaluated, in normal human adult volunteers (n = 30) using an open randomized crossover design protocol following a 10 mg intravenous or intramuscular injection. 2 Blood samples were collected for up to 12 h after the intravenous and up to 72 h after the intramuscular injections and the phylloquinone (vitamin K-1) levels determined by reversed phase h.p.l.c. with fluorometric detection after post-column electrochemical reduction. 3 Konakion(R) MM was well tolerated after either route of administration. Pharmacokinetic analysis of plasma phylloquinone (vitamin K-1) concentration vs time profiles revealed that in one-fifth of the subjects systemic availability of intramuscular phylloquinone (vitamin K-1) was below 65%. 4 Our data suggest that due to sustained, but irregular and unpredictable absorption of the phylloquinone (vitamin K-1) from the depot site, the intramuscular route of Konakion(R) MM administration is not suitable and thus not recommended. 5 Konakion(R) MM i.v. is indicated to be well tolerated and effective in antagonizing coumarin-type-anticoagulants like Marcoumar(R) |
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Language
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English
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Source (journal)
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British journal of clinical pharmacology. - London
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Publication
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London
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1996
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ISSN
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0306-5251
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DOI
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10.1046/J.1365-2125.1996.03847.X
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Volume/pages
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41
:6
, p. 517-523
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ISI
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A1996UP45400006
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Full text (Publisher's DOI)
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