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Title
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Synthesis, conformational analysis and biological evaluation of 2-(5-deoxy-β-D-ribofuranosyl)pyridine-4-carboxamide
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Author
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Abstract
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| Coupling of 5-deoxy-2,3-(O) under bar-isopropylidene-(D) under bar-ribono-1,4-lactone (5) with 2-lithio-4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridine (6), subsequent mesylation, followed by reduction and ammonolysis resulted in the formation of 2-(5-deoxy-beta-(D) under bar-ribofuranosyl)pyridine-4-carboxamide (4). The anomeric configuration was established with 2D-NOESY-H-1-nmr-spectroscopy. Conformational analysis was done with the aid of the high resolution H-1-nmr-spectroscopy data. Compound (4) possessed modest cytostatic activity against a number of tumor cell lines and was slightly inhibitory to vaccinia virus and vesicular stomatitis virus. |
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Language
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English
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Source (journal)
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Heterocycles. - Sendai
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Publication
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Sendai
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1996
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ISSN
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0385-5414
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Volume/pages
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42
:1
(1996)
, p. 173-187
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ISI
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A1996TQ11300032
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