Title
Localization of a gene for non-syndromic hearing-loss (dfna5) to chromosome 7p15 Localization of a gene for non-syndromic hearing-loss (dfna5) to chromosome 7p15
Author
Publication type
article
Publication
Oxford ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Human molecular genetics. - Oxford
Volume/pages
4() :11 , p. 2159-2163
ISSN
0964-6906
ISI
A1995TD65900022
Carrier
E
Target language
English (eng)
Abstract
Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing Toss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.
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