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Title
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Gene conversion between red and defective green opsin gene in blue cone monochromacy
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Author
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Abstract
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| Blue cone monochromacy is an X-linked condition in which the function of both the red pigment gene (RCP) and the green pigment gene (GCP) is impaired. Blue cone monochromacy can be due to a red/green gene array rearrangement existing of a single red/green hybrid gene and an inactivating C203R point mutation in GCP. We describe here a family with blue cone monochromacy due to the presence of the C203R mutation in both RCP and GCP. The flanking sequences of the C203R mutation in exon 4 of RCP were characteristic for GCP, indicating that this mutation was transferred from GCP into RCP by gene conversion. (C) 1995 Academic Press, Inc. |
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Language
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English
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Source (journal)
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Genomics: international journal of gene mapping and nucleotide sequencing. - San Diego, Calif.
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Publication
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San Diego, Calif.
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1995
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ISSN
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0888-7543
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DOI
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10.1006/GENO.1995.9998
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Volume/pages
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29
:2
(1995)
, p. 323-328
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ISI
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A1995RY05500002
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Full text (Publisher's DOI)
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