Title
Apolipoprotein-e genotype and association between smoking and early-onset alzheimers-disease Apolipoprotein-e genotype and association between smoking and early-onset alzheimers-disease
Author
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
British medical journal / British Medical Association. - London
Volume/pages
310() :6980 , p. 627-631
ISSN
0959-8138
ISI
A1995QL98400015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Objective-To investigate the hypothesis that differential survival between smokers and nonsmokers leading to a decrease in the frequency of the e4 allele of the apolipoprotein E gene may explain the inverse relation between smoking history and early onset Alzheimer's disease. Design-A population based case-control study. Setting-The four northern provinces of the Netherlands and metropolitan Rotterdam. Subjects-175 patients with early onset Alzheimer's disease and two independent control groups of 159 and 457 subjects. Main outcome measures-Frequencies of the apolipoprotein e4 allele and relative risk of early onset Alzheimer's disease, Results-The inverse association between smoking history and early onset Alzheimer's disease could not be explained by a decrease in the frequency the apolipoprotein e4 allele, Among of this allele with a family history of dementia subjects with a history of smoking had a strongly reduced risk of early onset Alzheimer's disease (odds ratio 0.10 (95% confidence interval 0.01 to 0.87)). Conclusions-The results suggest that the inverse relation between smoking history and early onset Alzheimer's disease cannot be explained by an increased mortality in carriers of the apolipoprotein e4 allele who smoke, The association is strongly modified by the presence of the apolipoprotein e4 allele as well as by a family history of dementia.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98400015&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98400015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98400015&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848