Publication
Title
Apolipoprotein-e genotype and association between smoking and early-onset alzheimers-disease
Author
Abstract
Objective-To investigate the hypothesis that differential survival between smokers and nonsmokers leading to a decrease in the frequency of the e4 allele of the apolipoprotein E gene may explain the inverse relation between smoking history and early onset Alzheimer's disease. Design-A population based case-control study. Setting-The four northern provinces of the Netherlands and metropolitan Rotterdam. Subjects-175 patients with early onset Alzheimer's disease and two independent control groups of 159 and 457 subjects. Main outcome measures-Frequencies of the apolipoprotein e4 allele and relative risk of early onset Alzheimer's disease, Results-The inverse association between smoking history and early onset Alzheimer's disease could not be explained by a decrease in the frequency the apolipoprotein e4 allele, Among of this allele with a family history of dementia subjects with a history of smoking had a strongly reduced risk of early onset Alzheimer's disease (odds ratio 0.10 (95% confidence interval 0.01 to 0.87)). Conclusions-The results suggest that the inverse relation between smoking history and early onset Alzheimer's disease cannot be explained by an increased mortality in carriers of the apolipoprotein e4 allele who smoke, The association is strongly modified by the presence of the apolipoprotein e4 allele as well as by a family history of dementia.
Language
English
Source (journal)
British medical journal / British Medical Association. - London
Publication
London : 1995
ISSN
0959-8146 [International]
0959-8138 [Clinical research]
0959-8154 [General practice]
0959-535X [Compact]
1468-5833 [online]
Volume/pages
310:6980, p. 627-631
ISI
A1995QL98400015
Full text (Publishers DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 29.02.2012
Last edited 11.05.2017