Title
Plasma-soluble interleukin-2 and transferrin receptor in schizophrenia and major depression Plasma-soluble interleukin-2 and transferrin receptor in schizophrenia and major depression
Author
Publication type
article
Publication
Berlin ,
Subject
Human medicine
Source (journal)
European archives of psychiatry and clinical neuroscience. - Berlin
Volume/pages
244() :6 , p. 325-329
ISSN
0940-1334
ISI
A1995QF89900008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
This study was carried out to examine some components of in vivo immune function in major depression and schizophrenia. Toward this end, plasma concentrations of interleukin-1 beta (IL-1 beta) and IL-6, soluble IL-2 receptor (sIL-2R), and transferrin receptor (TfR) were measured in 28 normal controls, 11 schizophrenics and 13 major-depressed patients. Schizophrenic and major-depressed patients showed significantly higher plasma sIL-2R and TfR than normal controls. There was a trend toward higher plasma IL-6 in the psychiatric patients, and particularly in schizophrenic patients, than in normal volunteers. In normal controls and in the total study group, there were highly significant and positive correlations between plasma TfR and sIL-2R concentrations. It is suggested that schizophrenia and major depression are characterized by immune disorders that may indicate activation of cell-mediated immunity such as T-cell activation.
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