Title
Detection of numerical chromosomal-aberrations in paraffin-embedded malignant pleural mesothelioma by nonisotopic in-situ hybridization Detection of numerical chromosomal-aberrations in paraffin-embedded malignant pleural mesothelioma by nonisotopic in-situ hybridization
Author
Publication type
article
Publication
Edinburgh ,
Subject
Human medicine
Source (journal)
The journal of pathology. - Edinburgh
Volume/pages
175() :2 , p. 219-226
ISSN
0022-3417
ISI
A1995QG80300009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
An in situ hybridization (ISH) study on paraffin sections of 13 malignant mesotheliomas was performed to detect numerical chromosomal aberrations with biotin-labelled DNA probes specific for the centromeric regions of chromosomes 1, 3, 6, 7, 11, and 17. All chromosomes contributed to numerical changes, which can be summarized as follows: first, a monosomy for chromosome 6 was found in one case; second, in five cases a trisomy for at least one chromosome was detected; and third, in seven cases a pentasomy or a higher polysomy was found for at least one chromosome. Although these data have to be confirmed on a larger group of patients, survival analysis of this group showed no significant difference between the first and second groups taken together and the third group. In this study no specific numerical chromosomal aberrations were identified. Nevertheless, numerical gains appear to be more frequent than has previously been shown by karyotype analysis.
E-info
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