Title
Development of poly (dialkyl methylidenemalonate) nanoparticles as drug carriers Development of poly (dialkyl methylidenemalonate) nanoparticles as drug carriers
Author
Publication type
article
Publication
Amsterdam ,
Subject
Pharmacology. Therapy
Source (journal)
International journal of pharmaceutics. - Amsterdam
Volume/pages
92() :1-3 , p. 71-79
ISSN
0378-5173
ISI
A1993LE89100009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs.
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