Publication
Title
Development of poly (dialkyl methylidenemalonate) nanoparticles as drug carriers
Author
Abstract
Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs.
Language
English
Source (journal)
International journal of pharmaceutics. - Amsterdam
Publication
Amsterdam : 1993
ISSN
0378-5173
Volume/pages
92:1-3, p. 71-79
ISI
A1993LE89100009
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 29.02.2012
Last edited 09.12.2017