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Title
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Development of poly (dialkyl methylidenemalonate) nanoparticles as drug carriers
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Author
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Abstract
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| Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs. |
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Language
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English
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Source (journal)
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International journal of pharmaceutics. - Amsterdam
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Publication
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Amsterdam
:
1993
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ISSN
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0378-5173
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DOI
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10.1016/0378-5173(93)90265-H
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Volume/pages
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92
:1-3
, p. 71-79
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ISI
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A1993LE89100009
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Full text (Publisher's DOI)
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