Publication
Title
Influence of aging on fluidity and coupling between beta-receptors and g-proteins in rat lung membranes
Author
Abstract
We tested the hypothesis that in rat lung membranes, the age-related decline in the percentage of beta-receptors coupled with high affinity to G-proteins, is due to limitation of the diffusion caused by a decrease in membrane fluidity. We measured both parameters simultaneously in a crude membrane preparation from lungs of rat of different age. In contrast to what is found in crude membrane preparations from rat liver and brain, in rat lung fluidity was increased upon aging. We conclude that the age-related alteration in coupling between receptor and G-protein is difficult to explain by alterations of membrane fluidity.
Language
English
Source (journal)
Life sciences. - Oxford
Publication
Oxford : 1993
ISSN
0024-3205
0300-9653
Volume/pages
53:2, p. 153-160
ISI
A1993LF44100008
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 29.02.2012
Last edited 28.07.2017