Title
Influence of aging on fluidity and coupling between beta-receptors and g-proteins in rat lung membranes Influence of aging on fluidity and coupling between beta-receptors and g-proteins in rat lung membranes
Author
Publication type
article
Publication
Oxford ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Life sciences. - Oxford
Volume/pages
53() :2 , p. 153-160
ISSN
0024-3205
ISI
A1993LF44100008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We tested the hypothesis that in rat lung membranes, the age-related decline in the percentage of beta-receptors coupled with high affinity to G-proteins, is due to limitation of the diffusion caused by a decrease in membrane fluidity. We measured both parameters simultaneously in a crude membrane preparation from lungs of rat of different age. In contrast to what is found in crude membrane preparations from rat liver and brain, in rat lung fluidity was increased upon aging. We conclude that the age-related alteration in coupling between receptor and G-protein is difficult to explain by alterations of membrane fluidity.
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