Removal of aluminoxamine and ferrioxamine by charcoal hemoperfusion and hemodialysis
We studied the removal of aluminoxamine (AlO) and ferrioxamine (FO) by (i) hemoperfusion/hemodialysis using an AluKart(R) in combination with either a Cuprophan(R) F-120 or a Hemophan(R) FH-160 membrane, or (ii) hemodialysis with a high-flux F-60 polysulfone membrane. The same six dialysis patients underwent in a random order dialysis by the three set-ups after i.v. infusion of 30 mg/kg of desferrioxamine (DFO) during the last half an hour of the preceding dialysis session. The mean +/- SD plasma AlO and FO clearances of the AluKart(R) combined with either a F-120 or FH-160 membrane were 194.3 +/- 25.8 ml/min (AlO) and 164.2 +/- 41.3 ml (FO) at the start of dialysis declining to respectively 76.6 +/- 27.3 and 68.5 +/- 42.6 ml/min at the end of dialysis. With a high-flux dialysis membrane the intra-dialytic plasma clearance remained constant at 81.5 +/- 6.8 ml/min for AlO and 60.0 +/- 2.8 ml/min for FO. In the presence of an AluKart(R) combined with a FH-160 up to 84 +/- 27% and 84 +/- 19% of the available AlO and FO could be removed during a four-hour hemoperfusion/hemodialysis session. During the first hour of dialysis, respectively 59 and 58% of the total amount of AlO and FO extracted by the AluKart(R) was removed compared to only 9 and 16% during the last hour. We conclude that the combined use of hemoperfusion/hemodialysis is highly effective followed closely by a high-flux F-60 membrane in the removal of AlO and FO and in combination with low (5 to 10 mg/kg) DFO doses, may reduce the risk for side effects that have been associated with these compounds.
Source (journal)
Kidney international / International Society of Nephrology. - New York, N.Y., 1972, currens
New York, N.Y. : 1992
0085-2538 [print]
1523-1755 [online]
41:5, p. 1400-1407
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Creation 29.02.2012
Last edited 14.06.2017