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Title
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Influence of pgf2-alpha on gastrointestinal activity in the conscious piglet
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Author
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Abstract
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| In 5 conscious piglets with electrodes implanted on the antrum pylori, duodenum, jejunum and ileum, the effect of intravenous infusion of PGF2-alpha, 1 and 10-mu-g/kg/min during 2 h, on gastrointestinal electrical activity was studied. The influence of the PG, 10(-8) to 10(-4) M, on longitudinal tissue strips from the same segments was also examined. The in vitro results demonstrate that PGF2-alpha has only a weak contractile effect on duodenal and jejunal strips. This effect was enhanced in the presence of atropine and indomethacin. In the in vivo part of the study PGF2-alpha induced an inhibition of antral electrical activity as evidenced by a prolongation of the inhibitory phases and a reduction of the frequency of the fast oscillations. In the small intestine only ileal activity was changed significantly. PGF2-alpha, provoked an increase in the phase II or irregular spiking activity and an increase in the interval of the migrating myoelectrical complexes in this segment. |
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Language
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English
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Source (journal)
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Prostaglandins, leukotrienes and essential fatty acids. - New York, N.Y.
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Publication
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New York, N.Y.
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1992
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ISSN
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0952-3278
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DOI
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10.1016/0952-3278(92)90105-R
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Volume/pages
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45
:1
(1992)
, p. 71-75
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ISI
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A1992GZ13800009
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Full text (Publisher's DOI)
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