Title
Influence of pgf2-alpha on gastrointestinal activity in the conscious piglet Influence of pgf2-alpha on gastrointestinal activity in the conscious piglet
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Prostaglandins, leukotrienes and essential fatty acids. - New York, N.Y.
Volume/pages
45(1992) :1 , p. 71-75
ISSN
0952-3278
ISI
A1992GZ13800009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
In 5 conscious piglets with electrodes implanted on the antrum pylori, duodenum, jejunum and ileum, the effect of intravenous infusion of PGF2-alpha, 1 and 10-mu-g/kg/min during 2 h, on gastrointestinal electrical activity was studied. The influence of the PG, 10(-8) to 10(-4) M, on longitudinal tissue strips from the same segments was also examined. The in vitro results demonstrate that PGF2-alpha has only a weak contractile effect on duodenal and jejunal strips. This effect was enhanced in the presence of atropine and indomethacin. In the in vivo part of the study PGF2-alpha induced an inhibition of antral electrical activity as evidenced by a prolongation of the inhibitory phases and a reduction of the frequency of the fast oscillations. In the small intestine only ileal activity was changed significantly. PGF2-alpha, provoked an increase in the phase II or irregular spiking activity and an increase in the interval of the migrating myoelectrical complexes in this segment.
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