Title
Epistaxis or epiphora as a sign for extension of a conjunctival melanoma : a series of six patients with nasolacrimal recurrence Epistaxis or epiphora as a sign for extension of a conjunctival melanoma : a series of six patients with nasolacrimal recurrence
Author
Faculty/Department
University Hospital Antwerp
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
British journal of ophthalmology. - London
Volume/pages
94(2010) :10 , p. 1328-1331
ISSN
0007-1161
ISI
000283097700014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose To characterise malignant conjunctival melanomas with extension and recurrence in the nasolacrimal system. Methods Localisation of the primary tumour and recurrences of 210 conjunctival melanomas treated in The Netherlands were reviewed for orbital and nasal tumours (1978-2008). Based of these cases and literature data, characteristics for nasolacrimal system extension and metastasis were reviewed. Results Six patients (3%) showed a recurrence of the primary conjunctival melanoma in the nasolacrimal system. Two of the six primary tumours were limbal tumours; the other four were diffuse tumours involving the fornix. In all six patients, the primary conjunctival melanomas were associated with primary acquired melanosis. During the follow-up period (11.6 +/- 3 years, range 3.4-28.5 years, median 8.7 years) two patients developed metastases and died. Conclusions Patients should be advised to contact their treating ophthalmologist in the case of symptoms of epiphora, nose obstructions and epistaxis, especially non-bulbar and diffuse cases associated with primary acquired melanosis.
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