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Title
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Repeated administration of a reduced-antigen-content diphtheria-tetanus-acellular pertussis and poliomyelitis vaccine (dTpa-IPV; Boostrix (TM) IPV)
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Author
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Abstract
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| Background: The rising incidence of pertussis amongst adults and adolescents in industrialized countries could be reduced by replacing tetanus and diphtheria (Td) boosters with reduced-antigen-content dT-acellular pertussis (dTpa) vaccines. Repeated administration of a dTpa-IPV (dTpa-inactivated poliomyelitis; Boostrix (TM) Polio, GlaxoSmithKline) booster to adolescents, 5 years after their previous dose was evaluated. Results: Before the second dTpa-IPV booster, the percentage of subjects who were seroprotected/seropositive was: 98.2% (D); 98.5% (T); 40.6% (PT); 99.7% (FHA); 97.0% (PRN); 98.8% (anti-polio 1); 99.7% (anti-polio 2); 97.0% (anti-polio 3). One month after the second dTpa-IPV dose, all subjects were seroprotected against D, T and polio and anti-pertussis booster responses (seroconversion or >= 2-fold increase) were seen in 93.3% (PT), 93.4% (FHA) and 95.2% (PRN) of subjects. During 4-day follow-up, 4.1% subjects recorded grade 3 pain; 4.6% and 3.6% recorded redness or swelling >50 mm, respectively. No serious adverse events were recorded. The incidence of symptoms was not higher than after the previous booster. Methods: 415 subjects (mean age 11.4 years) who had received either dTpa-IPV or dTpa + IPV at age 4-8 years, all received one dose of dTpa-IPV in this open, phase IV trial. Blood samples were taken before and one-month post-vaccination. Antibody concentrations against D, T, pertussis toxoid (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and polio antigens were determined. Reactogenicity and safety was assessed. Conclusions: A second dTpa-IPV booster was highly immunogenic and well tolerated in this population of adolescents, supporting the repeated administration of Boostrix (TM) Polio. |
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Language
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English
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Source (journal)
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Human vaccines
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Publication
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2010
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ISSN
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1554-8600
1554-8619
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DOI
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10.4161/HV.6.7.11760
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Volume/pages
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6
:7
, p. 554-561
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ISI
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000284594100013
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Full text (Publisher's DOI)
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