Title
Cefepime and mortality: A real issue? Cefepime and mortality: A real issue?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Stockholm ,
Subject
Human medicine
Source (journal)
Scandinavian journal of infectious diseases. - Stockholm
Volume/pages
42(2010) :6-7 , p. 545-548
ISSN
0036-5548
ISI
000279896500024
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The fourth-generation cephalosporin, cefepime, has an antimicrobial spectrum that makes it a valuable antibiotic for empirical treatment of neutropenic fever. Randomized trials have proven the efficacy and safety of cefepime in neutropenic fever. However, 2 recent meta-analyses have shown an increased all-cause mortality for cefepime. Since then, many clinicians have been left in doubt about the use of cefepime for this indication. In this paper, we put in perspective some of the methodological and clinical issues and call for further clinical analyses.
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