Title
PAI-1 activity, but not fibrinogen or von Willebrand factor, is inversely retated to LDL particte size in type 2 diabetes
Author
Faculty/Department
Faculty of Medicine and Health Sciences
University Hospital Antwerp
Publication type
article
Publication
Chichester ,
Subject
Human medicine
Source (journal)
Diabetes/metabolism research and reviews. - Chichester
Volume/pages
24(2008) :2 , p. 141-147
ISSN
1520-7552
ISI
000253616200009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background Levels of fibrinogen, von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) have been associated with small low-density lipoprotein (LDL) particles. However, it is not clear whether these associations are independent of visceral adiposity or other components of the metabolic syndrome such as triglycerides or insulin resistance. Methods Visceral adipose tissue (VAT; CT-scan), fibrinogen, von Willebrand factor antigen (vWF: Ag), PAI-1 activity and different metabolic parameters such as total cholesterol (chol), HDL-chol, triglycerides, insulin resistance (homeostasis model assessment; HOMA-IR) were determined in 41 women and 78 men with type 2 diabetes. LDL particle size was assessed by polyacrylamide gradient gel electrophoresis. Results PAI-1 activity was inversely related to LDL particle size after adjustment for age and body mass index (BMI) (r = -0.28; p = 0.006) or age and VAT (r = -0.26; p = 0.01), but not after adjustment for age and HOMA-IR (r = -0.15; p = 0.148) or age and triglycerides (r = -0.04; p = 0.679). in multiple regression analysis, LDL particle size did not independently determine PAI-1 activity levels. Fibrinogen and vWF: Ag did not seem to be related to LDL size. Conclusions PAI-1 activity levels, in contrast to fibrinogen and vWF:Ag, seem to be related to the small LDL phenotype in patients with type 2 diabetes. However, this relationship was not independent of insulin resistance or triglycerides. Copyright (c) 2007 John Wiley & Sons, Ltd.
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