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Title
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Quantification of tumour microvascular permeability in human glioma xenografts using dynamic T-1 MRI with Gadomer-17
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Author
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Abstract
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| Dynamic Magnetic Resonance Imaging (T-1-mapping) using the Gadolinium complex Gadomer-17, was applied to characterise the vascular permeability of human glioma xenografts implanted in nude mice. We aimed at measuring permeability differences in two types of glioma xenograft lines with a known difference in perfusion status. The T-1-data could be analysed according to the Tofts-Kermode compartmental model for modelling tracer kinetics to vascular permeability. This vascular permeability was mapped as the permeability surface area product per unit of leakage volume (k). The two tumour types displayed different k-maps. For the fast growing E102 tumour, we observed a homogeneous distribution of the vascular permeability across the tumour with a mean k-value of (0.207 +/- 0.027) min(-1). However, for the slowly growing E106 tumour, we could distinguish four different regions with different permeability characteristics: a well-perfused rim (k= (0.30 +/- 0.09) min(-1)), regions at the inner side of the tumour with lower permeability (k=(0.130 +/- 0.019) min(-1)), regions at the inner side of the tumour around necrotic regions demonstrating locally increased permeability (k= (0.33 +/- 0.11) min(-1)), and necrotic regions. |
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Language
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English
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Source (journal)
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Proceedings of the Society of Photo-optical Instrumentation Engineers / SPIE: International Society for Optical Engineering. - Bellingham, Wash.
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Source (book)
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Medical Imaging 1999 Conference, Feb. 21-25, 1999, San Diego, Calif.
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Publication
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Bellingham
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Spie-int soc optical engineering
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1999
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ISBN
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0-8194-3132-X
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DOI
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10.1117/12.349612
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Volume/pages
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3660
(1999)
, p. 418-428
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ISI
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000081442700042
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Full text (Publisher's DOI)
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