Title
The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
New York ,
Subject
Human medicine
Computer. Automation
Source (journal)
Neuroimage. - New York
Volume/pages
59(2012) :3 , p. 2208-2216
ISSN
1053-8119
ISI
000299494000023
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In diffusion tensor magnetic resonance imaging (DT-MRI), limitations concerning complex fiber architecture (when an image voxel contains fiber populations with more than one dominant orientation) are well-known. Fractional anisotropy (FA) values are lower in such areas because of a lower directionality of diffusion on the voxel-scale, which makes the interpretation of FA less straightforward. Moreover, the interpretation of the axial and radial diffusivities is far from trivial when there is more than one dominant fiber orientation within a voxel. In this work, using (i) theoretical considerations, (ii) simulations, and (iii) experimental data, it is demonstrated that the mean diffusivity (or the trace of the diffusion tensor) is lower in complex white matter configurations, compared with tissue where there is a single dominant fiber orientation within the voxel. We show that the magnitude of this reduction depends on various factors, including configurational and microstructural properties (e.g., the relative contributions of different fiber populations) and acquisition settings (e.g., the b-value). These results increase our understanding of the quantitative metrics obtained from DTMRI and, in particular, the effect of the microstructural architecture on the mean diffusivity. More importantly, they reinforce the growing awareness that differences in DT-MRI metrics need to be interpreted cautiously. (C) 2011 Published by Elsevier Inc.
E-info
https://repository.uantwerpen.be/docman/iruaauth/9f6019/44f1223.pdf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299494000023&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299494000023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299494000023&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle