Title
Anti-inflammatory potential of probiotics : lipoteichoic acid makes a difference Anti-inflammatory potential of probiotics : lipoteichoic acid makes a difference
Author
Faculty/Department
Faculty of Sciences. Bioscience Engineering
Publication type
article
Publication
Cambridge ,
Subject
Chemistry
Biology
Engineering sciences. Technology
Source (journal)
Trends in microbiology. - Cambridge
Volume/pages
20(2012) :1 , p. 5-10
ISSN
0966-842X
ISI
000300656000002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Lipoteichoic acid (LTA) mutants of lactobacilli suppress inflammation in animal models of experimental colitis. The fact that a single mutation of an administered Lactobacillus strain can result in enhanced probiotic efficacy is surprising given the genetic diversity and complexity of the intestinal niche, but at the same time exciting from a microbiological, immunological and gastroenterological point of view. In this Opinion article, we discuss the possible impacts of LTA modification in probiotic bacteria in the context of the current knowledge regarding the proinflammatory capacity of LTA, structureactivity relationships of LTA, intestinal LTA recognition in healthy and colitis conditions and anti-inflammatory molecules of lactobacilli.
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