Publication
Title
Anti-inflammatory potential of probiotics : lipoteichoic acid makes a difference
Author
Abstract
Lipoteichoic acid (LTA) mutants of lactobacilli suppress inflammation in animal models of experimental colitis. The fact that a single mutation of an administered Lactobacillus strain can result in enhanced probiotic efficacy is surprising given the genetic diversity and complexity of the intestinal niche, but at the same time exciting from a microbiological, immunological and gastroenterological point of view. In this Opinion article, we discuss the possible impacts of LTA modification in probiotic bacteria in the context of the current knowledge regarding the proinflammatory capacity of LTA, structureactivity relationships of LTA, intestinal LTA recognition in healthy and colitis conditions and anti-inflammatory molecules of lactobacilli.
Language
English
Source (journal)
Trends in microbiology. - Cambridge
Publication
Cambridge : 2012
ISSN
0966-842X
Volume/pages
20:1(2012), p. 5-10
ISI
000300656000002
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 14.03.2012
Last edited 08.08.2017
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