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Title
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Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)
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Author
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Abstract
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| Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups. |
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Language
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English
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Source (journal)
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Bioorganic and medicinal chemistry. - Oxford
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Publication
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Oxford
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2012
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ISSN
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0968-0896
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DOI
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10.1016/J.BMC.2011.12.040
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Volume/pages
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20
:4
(2012)
, p. 1557-1568
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ISI
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000300391200022
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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