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Title
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Additional value of PET-CT in staging of clinical stage IIB and III breast cancer
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Author
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Abstract
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| To evaluate retrospectively the accuracy of integrated PET/CT, against PET, CT, or conventional staging in breast cancer. Seventy consecutive biopsy proven clinical stage IIB and III breast cancer patients were included. Descriptive statistics of integrated PET/CT for the primary tumor, nodal status and metastasis detection were compared to PET, CT with contrast, and conventional staging (biochemistry, chest X-ray, liver ultrasound, and bone scintigraphy). Sensitivity of PET/CT for primary tumor and nodal status was 97.1% and 62.5%, respectively. Specificity and negative predictive value for nodal status were 100% and 66.6%, respectively. The values for conventional staging for nodal involvement were 100% and 85.7% with a sensitivity of 87.5%. PET/CT showed metastatic disease in seven women despite normal conventional staging. PET/CT is able to visualize most clinical stage IIB and III primary breast cancers. PET/CT is superior to conventional staging for detecting internal mammary chain nodes and metastatic disease, but not for axillary staging. Future studies will have to test whether therapy adjustment based on PET/CT has the potential to improve survival. |
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Language
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English
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Source (journal)
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Breast journal. - Oxford
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Publication
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Oxford
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2010
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ISSN
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1075-122X
[print]
1524-4741
[online]
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DOI
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10.1111/J.1524-4741.2010.00987.X
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Volume/pages
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16
:6
(2010)
, p. 617-624
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ISI
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000284171400008
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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