Title
Efficacy of daily intake of **Lactobacillus casei** Shirota on respiratory symptoms and influenza vaccination immune response : a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents Efficacy of daily intake of **Lactobacillus casei** Shirota on respiratory symptoms and influenza vaccination immune response : a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents
Author
Faculty/Department
Faculty of Sciences. Mathematics and Computer Science
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bethesda, Md ,
Subject
Human medicine
Source (journal)
The American journal of clinical nutrition. - Bethesda, Md
Volume/pages
95(2012) :5 , p. 1165-1171
ISSN
0002-9165
ISI
000303140700022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination. Objective: We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination. Design: Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥6.5 × 109 live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination. Results: Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown. Conclusion: The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277.
E-info
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