Publication
Title
The value of cerebrospinal fluid biomarkers for the differential diagnosis of dementia
Author
Abstract
The diagnostic markers for Alzheimers disease (AD) (b‑amyloid142, total tau protein and hyperphosphorylated tau) are gradually finding their way into routine clinical practice as an affirmative diagnostic tool, rather than an exclusionary one. Their discriminatory power for the differential diagnosis of dementia is, however, suboptimal and other cerebrospinal fluid biomarkers, especially those that are reflective of the pathology of the non-AD dementia etiologies, could improve the differential dementia diagnosis either by their individual use (diagnostic value) or in combination with the established AD biomarkers (added diagnostic value). Unfortunately, validated biomarkers for non-AD dementias do not yet exist, but promising candidates have been identified over recent years. This review summarizes the current literature on cerebrospinal fluid biomarkers for the diagnosis of AD and other dementias.
Language
English
Source (journal)
Neurodegenerative Disease Management
Publication
2012
ISSN
1758-2024
1758-2032
Volume/pages
2:2(2012), p. 211-219
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 19.04.2012
Last edited 02.10.2015
To cite this reference