Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic childrenNebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children
Faculty of Medicine and Health Sciences
Translational Pathophysiological Research (TPR)
Allergy: European journal of allergy and clinical immunology. - Copenhagen
42(1987):1, p. 33-36
University of Antwerp
Twenty children aged 3 to 14 years with a history of bronchial asthma complicated by chronic sinusitis were studied in a double-blind study. Patients received, at random, over a period of 2 weeks, either 2 ml saline or 2 ml bromhexine (2 mg/ml) t.i.d. by means of a home nebulizer. A significant decline of clinical symptoms during both nebulization treatments as compared to the pretreatment symptom score was observed (mean score of 1.5 ± 0.7 and 0.5 ± 0.8, respectively, (P 0.01). Both types of nebulization were equally efficient in reducing the symptom score. Radiological abnormalities were significantly more reversed after saline nebulization as compared with bromhexine (P< 0.05), although both treatments showed radiological improvement (P< 0.01). The present study indicates that nebulization with saline may have some beneficial effect on chronic sinusitis in asthmatic children. Bromhexine was not superior to saline for this purpose.