Title
DFNA5, a gene involved in hearing loss and cancer : a review DFNA5, a gene involved in hearing loss and cancer : a review
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
St. Louis, Mo. ,
Subject
Human medicine
Source (journal)
The annals of otology, rhinology and laryngology. - St. Louis, Mo., 1897, currens
Volume/pages
121(2012) :3 , p. 197-207
ISSN
0003-4894
ISI
000301695200010
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Objectives: The DFNA5 gene was identified in 1998 as a gene that causes an autosomal dominant form of hearing impairment. Five different DFNA5 mutations have been found; each results in skipping of exon 8 at the messenger RNA level. This finding indicates that DFNA5-associated hearing loss is attributable to a highly specific gain-of-function mutation. Interestingly, later reports revealed that DFNA5 also plays a role in tumor biology. Methods: Recent data have shed more light on the biological function of DFNA5. Through a literature search, the current knowledge of this gene is reviewed. Results: DFNA5 is the first gene for monogenic deafness that is known to involve apoptosis as a disease mechanism - a mechanism that was shown to be involved in frequent types of hearing loss caused by age, noise, or drugs. In line with its apoptosis-inducing properties, DFNA5 is a tumor suppressor gene with an important role in major types of tumors. Conclusions: DFNA5 is a tumor suppressor gene that is involved in apoptosis pathways and as such performs a basic role in cell survival. In view of the known role of apoptosis in several forms of hearing loss. DFNA5 may be a player in the underlying disease mechanisms.
E-info
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