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Title
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Microtubule dynamics in the peripheral nervous system : a matter of balance
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Author
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Abstract
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| The special architecture of neurons in the peripheral nervous system, with axons extending for long distances, represents a major challenge for the intracellular transport system. Two recent studies show that mutations in the small heat shock protein HSPB1, which cause an axonal type of Charcot-Marie-Tooth (CMT) neuropathy, affect microtubule dynamics and impede axonal transport. Intriguingly, while at presymptomatic age the neurons in the mutant HSPB1 mouse show a hyperstable microtubule network, at postsymptomatic age, the microtubule network completely lost its stability as reflected by a marked decrease in tubulin acetylation levels. We here propose a model explaining the role of microtubule stabilization and tubulin acetylation in the pathogenesis of HSPB1 mutations. |
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Language
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English
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Source (journal)
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Bioarchitecture
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Publication
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2011
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ISSN
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1949-0992
1949-100X
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DOI
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10.4161/BIOA.1.6.19198
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Volume/pages
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1
:6
(2011)
, p. 267-270
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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