Publication
Title
Seventeen-year antibody persistence in adults primed with two doses of an inactivated hepatitis A vaccine
Author
Abstract
Background and objectives Antibody persistence and immune memory against hepatitis A (HAV) in adults in a low endemicity country, 15 y after immunisation with two doses of HAV vaccine has been demonstrated. This communication provides additional information on antibody persistence up to Year 17 from two of the longest follow-up studies [NCT00289757/NCT00291876]. Methods In two double-blind primary studies, healthy adults aged 17−40 y and 21−40 y, respectively received two doses of the HAV vaccine following a 0,6 mo or 0,12 mo schedule. Anti-HAV antibody concentrations were measured using an enzyme-linked immunoassay (cut-off: 15mIU/ml) at Year 16 and Year 17. Subjects who became seronegative (anti-HAV < 15mIU/ml) since previous reporting were offered a challenge dose, with anti-HAV antibody concentration measurements at Day 14 and Day 30 thereafter. Results At Year 17, 100% and 96.7% of subjects remained seropositive for anti-HAV antibodies following the 0, 6 mo and 0, 12 mo regimens, respectively (GMCs: 278mIU/ml and 369mIU/ml). One subject who became seronegative at Year 16 received a HAV challenge dose within the next 12 mo and mounted an anamnestic response. The challenge dose was well-tolerated. Conclusions Both HAV immunisation regimens (0,6 mo and 0,12 mo) induced persistence of vaccine-induced antibodies against HAV for at least 17 y after primary vaccination.
Language
English
Source (journal)
Human vaccines & immunotherapeutics. - Philadelphia, Pa, 2012, currens
Publication
Philadelphia, Pa : 2012
ISSN
2164-5515 [print]
2164-554X [online]
DOI
10.4161/HV.18617
10.4161/HV.8.3.18617
Volume/pages
8 :3 (2012) , p. 323-327
ISI
000303057200015
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 31.05.2012
Last edited 09.10.2023
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