Title
Electrically silent Kv subunits : their molecular and functional characteristics Electrically silent Kv subunits : their molecular and functional characteristics
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Bethesda, Md. ,
Subject
Human medicine
Source (journal)
Physiology. - Bethesda, Md.
Volume/pages
27(2012) :2 , p. 73-84
ISSN
1548-9213
ISI
000302940000003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Electrically silent voltage-gated potassium (KvS) alpha-subunits do not form homotetramers but heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in which the KvS subunits modulate the Kv2 current. This poses intriguing questions into the molecular mechanisms by which these KvS subunits cannot form functional homotetramers, why they only interact with Kv2 subunits, and how they modulate the Kv2 current.
E-info
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