Title
Electrochemical sensing of phenicol antibiotics at gold Electrochemical sensing of phenicol antibiotics at gold
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Sciences. Chemistry
Publication type
article
Publication
Subject
Physics
Chemistry
Biology
Source (journal)
International journal of electrochemical science
Volume/pages
7(2012) :6 , p. 5000-5011
ISSN
1452-3981
ISI
000305267400014
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Phenicols are an effective and a broad spectrum class of antibiotics which has lost favour due to their side effects on human health. A rapid and sensitive electrochemical detection system is developed for the simultaneous detection of chloramphenicol (CAP), thiamphenicol (TAP) and florfenicol (FF). The electrochemical behaviour of CAP in the presence of its derivatives was investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV). At a gold electrode, CAP gives rise to a sensitive cathodic peak at −0.68V (versus SCE) in a tris buffer solution (pH 7.6). This behavior gives us the opportunity to introduce a method for sensing CAP electrochemically in the presence of its derivatives. Calibration graphs were linear in the 2.5-7.4 μmol L-1 concentration range. Deviations from linearity were observed for higher concentrations and this was interpreted to be due to kinetic limitation caused by the saturation of CAP and its reduction products onto the gold electrode surface. A limit of detection of 1 μmol L-1 was found.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/f96773/9d6d3d8d.pdf
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