Title
Minimum prevalence, birth incidence and cause of death for Prader-Willi syndrome in Flanders Minimum prevalence, birth incidence and cause of death for Prader-Willi syndrome in Flanders
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Leiden ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
European journal of human genetics / European Society of Human Genetics. - Leiden
Volume/pages
12(2004) :3 , p. 238-240
ISSN
1018-4813
ISI
000189078000011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The identification of all people with a diagnosis of PraderWilli syndrome (PWS) confirmed by DNA methylation analysis living in Flanders was attempted through contact with the four genetic centres and the PWS Association. The birth incidence for the period 19932001 was 1:26 676, the minimum prevalence at 31 December 2001 was 1:76 574. A decreasing number of cases with age was found, which can be explained by a number of missing cases in the older population, a higher neonatal mortality in the past and an increasing mortality with age. Childhood death is usually sudden and associated with respiratory infection and high temperature, while the cause of death in adults is considered to be circulatory or respiratory in origin.
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