Title
Histamine nasal provocation test : an evaluation of active anterior rhinomanometry and of threshold criteria of provocative dose Histamine nasal provocation test : an evaluation of active anterior rhinomanometry and of threshold criteria of provocative dose
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Copenhagen ,
Subject
Human medicine
Source (journal)
Allergy: European journal of allergy and clinical immunology. - Copenhagen
Volume/pages
44(1989) :7 , p. 482-486
ISSN
0105-4538
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
This study is a methodological approach to histamine nasal provocation. The test uses active anterior rhinomanometry and a histamine titration method, challenging both nasal cavities with a metered dose pump. It has been confirmed that the histamine nasal provocation test can differentiate between controls and non-allergic rhinitis patients. This study shows, moreover, that the method is more sensitive in assessing response to histamine provocation when a 25% increase of post-saline nasal airway resistance (PD25) is considered than a PD50 or PD100 criterion. The histamine response, was found to be independent of the baseline nasal airway resistance value. Pronounced unilateral responsiveness was frequently noticed. Both nasal cavities should be challenged and the most reactive side considered.
Handle