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Title
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Site-specific labeling of second generation annexin V with for improved imaging of apoptosis in vivo
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Author
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Abstract
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| In this study second generation AnxV was specifically labeled with 99mTc in three different ways outside the binding region of the protein to obtain an improved target-to-background activity ratio. The compounds were tested in vitro and in vivo in normal mice and in a model of hepatic apoptosis (anti-Fas mAb). The apoptosis binding was most prominent for the HIS-tagged second generation AnxV labeled with 99mTc(CO)3 in comparison to 99mTc-HYNIC-cys-AnxV and 99mTc(CO)3-DTPA-cys-AnxV. |
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Language
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English
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Source (journal)
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Bioorganic and medicinal chemistry. - Oxford
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Publication
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Oxford
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2010
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ISSN
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0968-0896
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Volume/pages
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18
:3
(2010)
, p. 1356-1363
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ISI
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000274153600042
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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