Title
[<tex>$^{18}F$</tex>]FDG PET monitoring of tumour response to chemotherapy : does [<tex>$^{18}F$</tex>]FDG uptake correlate with the viable tumour cell fraction? [<tex>$^{18}F$</tex>]FDG PET monitoring of tumour response to chemotherapy : does [<tex>$^{18}F$</tex>]FDG uptake correlate with the viable tumour cell fraction?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Heidelberg ,
Subject
Human medicine
Source (journal)
European journal of nuclear medicine and molecular imaging. - Heidelberg
Volume/pages
30(2003) :5 , p. 682-688
ISSN
1619-7070
ISI
000183421600008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Because metabolic changes induced by chemotherapy precede the morphological changes, fluorine-18 fluorodeoxyglucose positron emission tomography ([18F]FDG PET) is thought to predict response to therapy earlier and more accurately than other modalities. To be a reliable predictor of response, changes in tumour [18F]FDG uptake should reflect changes in viable cell fraction, but little is known about the contribution of apoptotic and necrotic cancer cells and inflammatory tissue to the [18F]FDG signal. In a tumour mouse model we investigated the relation between chemotherapy-induced changes in various tumoral components and tumour uptake and size. SCID mice were subcutaneously inoculated in the right thigh with 52106 Daudi cells. When the tumour measured 15-20 mm, Endoxan was given intravenously. At different time points [1-15 days (d1-d15) after the injection of Endoxan], ex vivo autoradiography and histopathology were performed in two mice and [18F]FDG uptake in the tumour and tumour size were correlated with the different cell fractions measured with flow cytometry in five mice. At d1/d3, similar reductions in [18F]FDG uptake and viable tumoral cell fraction were observed and these reductions preceded changes in tumour size. By d8/d10, [18F]FDG uptake had stabilised despite a further reduction in viable tumoral cell fraction. At these time points a major inflammatory response was observed. At d15, an increase in viable tumour cells was again observed and this was accurately predicted by an increase in [18F]FDG uptake, while the tumour volume remained unchanged. In contrast with variations in tumour volume, [18F]FDG is a good marker for chemotherapy response monitoring. However, optimal timing seems crucial since a transient increase in stromal reaction may result in overestimation of the fraction of viable cells.
E-info
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