Title
Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20 Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Amsterdam ,
Subject
Chemistry
Source (journal)
Colloids and surfaces: B : biointerfaces. - Amsterdam
Volume/pages
82(2011) :2 , p. 333-339
ISSN
0927-7765
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.511.0 exhibit a single well defined reduction peak which may be due to the reduction of Cdouble bond; length as m-dashC group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.87.2 μg mL−1. The calculated LOD and LOQ are 1.8 and 6.0 ng mL−1 by SWCAdSV and 8.1 and 27.2 ng mL−1 by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique.
E-info
https://repository.uantwerpen.be/docman/iruaauth/57a232/63cf0b1a354.pdf