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Title
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Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20
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Author
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Abstract
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| Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.511.0 exhibit a single well defined reduction peak which may be due to the reduction of Cdouble bond; length as m-dashC group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.87.2 μg mL−1. The calculated LOD and LOQ are 1.8 and 6.0 ng mL−1 by SWCAdSV and 8.1 and 27.2 ng mL−1 by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique. |
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Language
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English
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Source (journal)
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Colloids and surfaces: B : biointerfaces. - Amsterdam
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Publication
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Amsterdam
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2011
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ISSN
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0927-7765
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DOI
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10.1016/J.COLSURFB.2010.09.005
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Volume/pages
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82
:2
(2011)
, p. 333-339
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ISI
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000285858200010
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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