Title
Stripping voltammetry of tinidazole in solubilized system and biological fluidsStripping voltammetry of tinidazole in solubilized system and biological fluids
Author
Faculty/Department
Faculty of Sciences. Chemistry
Research group
AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Publication type
article
Publication
Amsterdam,
Subject
Chemistry
Source (journal)
Colloids and surfaces: A: physicochemical and engineering aspects. - Amsterdam
Volume/pages
378(2011), p. 27-33
ISSN
0927-7757
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0 × 10−9 to 6.2 × 10−7 mol/L with detection limit of 4.5 × 10−10 mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.
E-info
https://repository.uantwerpen.be/docman/iruaauth/fb59c1/94950cc6936.pdf