Title
The maximum uptake of <tex>$^{18}F$</tex>-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1<tex>$\alpha$</tex> and GLUT-1 in non-small cell lung cancer The maximum uptake of <tex>$^{18}F$</tex>-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1<tex>$\alpha$</tex> and GLUT-1 in non-small cell lung cancer
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
European journal of cancer. - Oxford, 1990, currens
Volume/pages
43(2007) :9 , p. 1392-1398
ISSN
0959-8049
ISI
000248089900020
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The purpose of this study was to investigate the relation between the standardised uptake value (SUV) on 18F-fluoro-2-deoxy-glucose-positron emission tomography scan and hypoxia related markers (HIF-1α and CAIX), a proliferation-related marker (Ki-67) and glucose transporters (GLUT-1 and GLUT-3) in non-small cell lung cancer (NSCLC). One hundred and two patients, scheduled for complete resection, received a PET scan in Leuven or Maastricht/Aachen. The maximal SUV (SUVmax) was correlated with survival and immunohistochemical staining patterns. The actuarial survival was worse for patients showing a high SUVmax, the best discriminative value being 8.0 (Leuven, p = 0.032) and 11.0 (Maastricht, p = 0.007). Tumours with a high SUVmax expressed in a higher proportion HIF-1α (63.1% versus 37.9%, p = 0.024) and GLUT-1 (82.9% versus 62.5%, p = 0.025), than tumours with a low SUVmax. No significant difference was found in the expression of CAIX, Ki-67 and GLUT-3. This study supports preclinical data that hypoxia is associated with a higher uptake of FDG.
E-info
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