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Title
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Unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer : the utility of positron emission tomography (PET)
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Author
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Abstract
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| The aim of the study was to evaluate the use of positron emission tomography with [18F]-fluorodeoxyglucose (FDG-PET) in patients with unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer. 50 consecutive patients with elevated CEA levels and a completely normal (n=31) or equivocal (n=19) conventional diagnostic work-up (CDW) were retrospectively selected. All PET images were reviewed with full knowledge of the CDW. The gold standard consisted of histology, or clinical follow-up of more than 1 year. Recurrent disease was established in 56 lesions in 43 patients. On a patient-based analysis, the sensitivity of FDG-PET was 34/43 (79%), and the positive predictive value 34/38 (89%). In 14/50 patients (28%), the FDG-PET findings led to a surgical resection with curative intent. On a lesion-based analysis, FDG-PET detected 42/56 lesions (sensitivity: 75%), the positive predictive value was 79% (42/53). These results demonstrate that FDG-PET can have a clear impact on patient management in patients with an unexplained elevation in CEA levels. |
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Language
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English
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Source (journal)
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European journal of cancer. - Oxford, 1990, currens
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Publication
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Oxford
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2001
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ISSN
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0959-8049
[print]
1879-0852
[online]
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DOI
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10.1016/S0959-8049(01)00049-1
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Volume/pages
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37
:7
(2001)
, p. 862-869
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ISI
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000168714800014
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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