Publication
Title
Can positron emission tomography with []-fluorodeoxyglucose after first-line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity?
Author
Abstract
To assess the ability of restaging positron emission tomography (PET) scanning to predict clinical outcome after first-line treatment in patients with Hodgkin's disease, we included 60 patients with histologically proven HD, who underwent whole-body [18F]-fluorodeoxygenase ([18F]-FDG)-PET studies after first-line treatment and with a follow-up of at least 1 year. Persistence or absence of residual disease on PET was related to progression-free survival (PFS) using KaplanMeier survival analysis. After treatment, 55 patients showed a normal [18F]-FDG-PET scan; 50 of 55 remained in complete remission (CR), with a median follow-up of 955 d. Only five patients relapsed (median PFS, 296 d). During follow-up in all five patients, [18F]-FDG-PET was the first tool that became positive for relapse. Persistent abnormal [18F]-FDG uptake was seen in only five patients; all of them relapsed (median PFS, 296 d). In four of five patients, only PET predicted persistent disease. All relapses were proven histologically. Two-year actuarial PFS rate for negative patients was 91% compared with 0% for positive patients. We concluded that [18F]-FDG-PET has an important prognostic role in the post-treatment evaluation of HD patients.
Language
English
Source (journal)
British journal of haematology. - Oxford
Publication
Oxford : 2001
ISSN
0007-1048
Volume/pages
115:2(2001), p. 272-278
ISI
000172403300007
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 19.06.2012
Last edited 30.05.2017