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Title
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Positron emission tomography in giant cell arteritis and polymyalgia rheumatica : evidence for inflammation of the aortic arch
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Author
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Abstract
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| Polymyalgia rheumatica, a clinical syndrome of proximal muscle pain and stiffness in older patients, is closely related to giant cell arteritis [1] and [2]. Many patients with giant cell arteritis have polymyalgia-like complaints (2). Polymyalgia rheumatica is diagnosed by the exclusion of other disorders that can cause similar complaints and by its rapid response to low-dose corticosteroid treatment [3] and [4]. The diagnosis of giant cell arteritis, on the other hand, requires a temporal artery biopsy; there are no noninvasive techniques to make that diagnosis. Positron emission tomography (PET) with a radiolabeled glucose analog, fluoro-18-deoxyglucose (18F-glucose), enables the in vivo measurements of glucose metabolism (5). 18F-glucose is transported across capillary and cell membranes in proportion to the rate of glucose uptake. PET with 18F-glucose is most often used in the assessment of cancer patients, because tumor cells have a greater glycolytic metabolism than normal tissue (6). However, increased glycolysis is also seen in activated leukocytes and macrophages [7] and [8]. Because giant cell arteritis and polymyalgia rheumatica are characterized by laboratory signs of inflammation, we evaluated the use of PET with 18F-glucose in these conditions. |
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Language
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English
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Source (journal)
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The American journal of medicine. - New York, N.Y.
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Publication
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New York, N.Y.
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2000
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ISSN
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0002-9343
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DOI
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10.1016/S0002-9343(99)00424-6
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Volume/pages
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109
:3
(2000)
, p. 246-249
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ISI
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000085334500009
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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