Title
Low CD4+ T cell counts among African HIV-1 infected subjects with **group B KIR** haplotypes in the absence of specific inhibitory KIR ligands Low CD4+ T cell counts among African HIV-1 infected subjects with **group B KIR** haplotypes in the absence of specific inhibitory KIR ligands
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Human medicine
Source (journal)
PLoS ONE
Volume/pages
6(2011) :2 , p. e17043,1-e17043,7
ISSN
1932-6203
Article Reference
e17043
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA). Genotypic combinations of KIR3DS1/L1 and HLA Bw4-80I were previously shown to influence HIV-1 disease progression, however other KIR genes have not been well studied. In this study, we analyzed the influence of all activating and inhibitory KIR, in association with the known HLA inhibitory KIR ligands, on markers of disease progression in a West African population of therapy-naïve HIV-1 infected subjects. We observed a significant association between carriage of a group B KIR haplotype and lower CD4+ T cell counts, with an additional effect for KIR3DS1 within the frame of this haplotype. In contrast, we found that individuals carrying genes for the inhibitory KIR ligands HLA-Bw4 as well as HLA-C1 showed significantly higher CD4+ T cell counts. These associations were independent from the viral load and from individual HIV-1 protective HLA alleles. Our data suggest that group B KIR haplotypes and lack of specific inhibitory KIR ligand genes, genotypes considered to favor NK cell activation, are predictive of HIV-1 disease progression.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/040fb9/95640608.pdf
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