Publication
Title
Case report : severe multifocal form of buruli ulcer after streptomycin and rifampin treatment : comments on possible dissemination mechanisms
Author
Abstract
Buruli ulcer (BU), a disease caused by Mycobacterium ulcerans, leads to the destruction of skin and sometimes bone. Here, we report a case of severe multifocal BU with osteomyelitis in a 6-year-old human immunodeficiency virus (HIV)-negative boy. Such disseminated forms are poorly documented and generally occur in patients with HIV co-infection. The advent of antibiotic treatment with streptomycin (S) and rifampin (R) raised hope that these multifocal BU cases could be reduced. The present case raises two relevant points about multifocal BU: the mechanism of dissemination that leads to the development of multiple foci and the difficulties of treatment of multifocal forms of BU. Biochemical (hypoproteinemia), hematological (anemia), clinical (traditional treatment), and genetic factors are discussed as possible risk factors for dissemination.
Language
English
Source (journal)
The American journal of tropical medicine and hygiene. - Baltimore, Md
Publication
Baltimore, Md : 2010
ISSN
0002-9637
Volume/pages
83:2(2010), p. 307-313
ISI
000280694300017
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 20.06.2012
Last edited 12.11.2017
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