Title
Family relationship, water contact and occurrence of buruli ulcer in Benin Family relationship, water contact and occurrence of buruli ulcer in Benin
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Human medicine
Source (journal)
PLoS neglected tropical diseases
Volume/pages
4(2010) :7 , p. e746,1-e746,6
ISSN
1935-2727
Article Reference
e746
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objectives This study aims to determine whether frequent contacts with natural water sources, family relationship or the practice of consanguineous marriages are associated with the occurrence of Buruli ulcer (BU). Design Case control study. Setting Department of Atlantique, Benin. Subjects BU-confirmed cases that were diagnosed and followed up at the BU detection and treatment center (CDTUB) of Allada (Department of the Atlantique, Benin) during the period from January 1st, 2006, to June 30th, 2008, with three matched controls (persons who had no signs or symptoms of active or inactive BU) for age, gender and village of residence per case. Main Outcomes Measured Contact with natural water sources, BU history in the family and the practice of consanguineous marriages. Results A total of 416 participants were included in this study, including 104 cases and 312 controls. BU history in the family (p<0.001), adjusted by daily contact with a natural water source (p = 0.007), was significantly associated with higher odds of having BU (OR; 95% CI = 5.5; 3.010.0). The practice of consanguineous marriage was not associated with the occurrence of BU (p = 0.40). Mendelian disorders could explain this finding, which may influence individual susceptibility by impairing immunity. Conclusion This study suggests that a combination of genetic factors and behavioral risk factors may increase the susceptibility for developing BU.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/5bf0a3/e9601334.pdf
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