Publication
Title
Polyphenols content, antioxidant and antiviral activities of leaf extracts of **Marrubium deserti** growing in Tunisia
Author
Abstract
Marrubium deserti de Noe is used in traditional medicine, for example as a remedy for asthma and diabetes, and was also found to have antibacterial properties. It is of particular interest in Tunisia and this is why we continued research on this plant. We here report on an investigation of its antioxidant and antiviral activities of petroleum ether, ethyl acetate, chloroform, butanol and methanol extracts. Total phenolic content of the extracts was determined by the Folin-Ciocalteu colorimetric method. The antioxidant activity was evaluated with the DPPH assay, the ABTS test and ammonium thiocyanate method. The antiviral activity was evaluated against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) and Coxsackie B virus type 3 (CoxB-3) using a cytopathic effect (CPE) reduction assay. With regards to IC50 values (50% inhibitory concentration) of scavenging abilities of the DPPH radical, methanol extract exhibited important antioxidant activities with IC50 of 0.150 mg/ml. The ethyl acetate extract showed the highest antioxidant activity using the linoleic acid emulsion system (79.23%). The butanol, methanol and ethyl acetate extracts showed significant antiviral activity against Coxsackie B3 virus. In conclusion, these results can be considered very promising and justify further research, amongst others on the identification of antioxidant and antiviral components in the active extracts. (C) 2012 SAAB. Published by Elsevier B.V. All rights reserved.
Language
English
Source (journal)
South African journal of botany. - Capetown
Publication
Capetown : 2012
ISSN
0254-6299
Volume/pages
80(2012), p. 104-109
ISI
000304838600015
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.07.2012
Last edited 16.06.2017
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