Title
Genetic markers for SSG-resistance in **Leishmania donovani** and SSG-treatment failure in visceral leishmaniasis patients of the Indian subcontinent Genetic markers for SSG-resistance in **Leishmania donovani** and SSG-treatment failure in visceral leishmaniasis patients of the Indian subcontinent
Author
Faculty/Department
Institute of Development Policy and Management
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Chicago, Ill. ,
Subject
Biology
Human medicine
Source (journal)
The journal of infectious diseases. - Chicago, Ill.
Volume/pages
206(2012) :5 , p. 752-755
ISSN
0022-1899
ISI
000307501800016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The current standard to assess pentavalent antimonial (SSG) susceptibility of Leishmania is a laborious in vitro assay of which the result has little clinical value since SSG-resistant parasites are also found in SSG-cured patients. Candidate genetic markers for clinically relevant SSG-resistant parasites identified by full genome sequencing were here validated on a larger set of clinical strains. We show that 3 genomic locations suffice to specifically detect the SSG-resistant parasites found only in patients experiencing SSG-treatment failure. This finding allows the development of rapid assays to monitor the emergence and spread of clinically relevant SSG-resistant Leishmania parasites.
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