Title
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Genetic markers for SSG-resistance in **Leishmania donovani** and SSG-treatment failure in visceral leishmaniasis patients of the Indian subcontinent
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Author
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Abstract
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The current standard to assess pentavalent antimonial (SSG) susceptibility of Leishmania is a laborious in vitro assay of which the result has little clinical value since SSG-resistant parasites are also found in SSG-cured patients. Candidate genetic markers for clinically relevant SSG-resistant parasites identified by full genome sequencing were here validated on a larger set of clinical strains. We show that 3 genomic locations suffice to specifically detect the SSG-resistant parasites found only in patients experiencing SSG-treatment failure. This finding allows the development of rapid assays to monitor the emergence and spread of clinically relevant SSG-resistant Leishmania parasites. |
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Language
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English
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Source (journal)
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The journal of infectious diseases. - Chicago, Ill.
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Publication
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Chicago, Ill.
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2012
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ISSN
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0022-1899
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DOI
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10.1093/INFDIS/JIS424
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Volume/pages
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206
:5
(2012)
, p. 752-755
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ISI
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000307501800016
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Full text (Publisher's DOI)
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