Title
Infusion of a lipid emulsion in healthy men decreases the serotonergic response Infusion of a lipid emulsion in healthy men decreases the serotonergic response
Author
Faculty/Department
University Hospital Antwerp
Publication type
article
Publication
Basel ,
Subject
Human medicine
Source (journal)
Neuroendocrinology. - Basel
Volume/pages
95(2012) :4 , p. 325-331
ISSN
0028-3835
ISI
000305551800007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Subjects with obesity and insulin resistance display a low response to a serotonergic challenge test. One of the hallmarks of obesity and insulin resistance is elevated plasma free fatty acids (FFAs). We hypothesize that increasing plasma FFA by infusion of a lipid emulsion, may be a contributing component leading to decreased serotonergic responsivity in healthy young men. Ten lean healthy men, 23.6 +/- 5.0 years and BMI 22.6 +/- 1.9 kg/m(2), were included. Serotonergic responsivity was assessed using the prolactin response to infusion with citalopram, a selective serotonin reuptake inhibitor, which is a validated tool to assess serotonergic tone. All participants received a lipid/heparin emulsion (Intralipid) infusion during 6 h. Saline infusion was used as a control. To evaluate a possible effect of heparin per se on prolactin, four out of the ten subjects also received heparin only during 6 h without the serotonergic challenge test. Plasma prolactin in-creased by 74.3 +/- 15.5% during saline infusion. Intralipid infusion increased plasma FFA from 0.5 +/- 0.05 to 2.3 +/- 0.2 mmol/l (p < 0.001). The increase in plasma prolactin during Intralipid infusion was significantly lower (39.3 +/- 10%; p < 0.001 compared to saline infusion). Heparin infusion per se increased plasma prolactin by 14.0 +/- 1.9%. We found that during the Intralipid infusion with concomitant high plasma FFA levels the serotonergic response was decreased in healthy young men. Higher FFA levels may be the mediator of the decreased serotonergic response reported in patients with insulin resistance and obesity. Copyright (C) 2012 S. Karger AG, Basel
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